6. Biosynthesis of aromatic amino acids.

The biosynthesis of aromatic amino acids phenylalanine, tyrosine, and tryptophan, takes multiple and complicated biochemical rections,most of them dealt with the formation of the ring structure.
Chorismate is the coommon intermediate for these 3 aromatic amino acids and is derived from erythrose-4-phosphate and phosphoenolpyruvate.
Complex amino acid biosynthetic pathways have been very useful and informative in studies on genetics and gene expression.
Biosynthesis of amino acid is feed-back regulated.
The enzyme that controls one of the early step is inhibited by the final product amino acid (excess tryptophan reduces the activity of anthranilate synthase).
Additional modes of regulation that fit different types of biosynthetic pathways.
Sequential feedback control
Enzyme multiplicity
Concerted feedback control


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