Metabolism of amino acids (II)
Amino acid metabolism
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Only half of the amino acids needed for protein synthesis in mammals (including
humans) are synthesized from within.
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Essential and non-essential amino acids.
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Excess amino acids are always degraded.
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Transamination reaction to dispose of nitrogen group.
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Oxidative deamination reactions.
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Removal of ammonia and urea cycle.
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Urea formation and energy requirements.
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Linking of urea and TCA cycle.
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Remaining carbon skeletons enter carbohydrate metabolic pathways
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Generation of energy from carbon skeletons from amino acid degradation.
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Genetic disorders resulting from defects in amino acid metabolism.
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Amino acids can serve as precusor for many other biologically important
and active compounds.
Subjects to be covered
1. Humans can synthesis less than half of the amino acids
needed.
2. Essential and non-essential amino acids.
3. Removal of amino groups of amino acids during
degradation.
4. Ammonia detoxification and urea cycle.
5. Degradation of carbon skeletons of amino acids.
6. Genetic diseases associated with amino acid catabolism.
7. Amino acids as the precursors of other compounds.
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